What are the consequences associated with PTSD?
PTSD is associated with a number of distinctive neurobiological and
physiological changes. PTSD may be associated with stable neurobiological
alterations in both the central and autonomic nervous systems, such as
altered brainwave activity, decreased volume of the hippocampus, and
abnormal activation of the amygdala. Both the hippocampus and the amygdala
are involved in the processing and integration of memory. The amygdala has
also been found to be involved in coordinating the body's fear response.
Psychophysiological alterations associated with PTSD include
hyper-arousal of the sympathetic nervous system, increased sensitivity of
the startle reflex, and sleep abnormalities.
People with PTSD tend to have abnormal levels of key hormones involved in
the body's response to stress. Thyroid function also seems to be enhanced in
people with PTSD. Some studies have shown that cortisol levels in those with
PTSD are lower than normal and epinephrine and norepinephrine levels are
higher than normal. People with PTSD also continue to produce higher than
normal levels of natural opiates after the trauma has passed. An important
finding is that the neurohormonal changes seen in PTSD are distinct from,
and actually opposite to, those seen in major depression. The distinctive
profile associated with PTSD is also seen in individuals who have both PTSD
and depression.
PTSD is associated with the increased likelihood of co-occurring
psychiatric disorders. In a large-scale study, 88 percent of men and 79
percent of women with PTSD met criteria for another psychiatric disorder.
The co-occurring disorders most prevalent for men with PTSD were alcohol
abuse or dependence (51.9 percent), major depressive episodes (47.9
percent), conduct disorders (43.3 percent), and drug abuse and dependence
(34.5 percent). The disorders most frequently comorbid with PTSD among women
were major depressive disorders (48.5 percent), simple phobias (29 percent),
social phobias (28.4 percent), and alcohol abuse/dependence (27.9 percent).
PTSD also significantly impacts psychosocial functioning, independent of
comorbid conditions. For instance, Vietnam veterans with PTSD were found to
have profound and pervasive problems in their daily lives. These included
problems in family and other interpersonal relationships, problems with
employment, and involvement with the criminal justice system.
Headaches, gastrointestinal complaints, immune system problems,
dizziness, chest pain, and discomfort in other parts of the body are common
in people with PTSD. Often, medical doctors treat the symptoms without being
aware that they stem from PTSD.
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